Developed by members of the ISTA Pharma Committee, this best practice guidance document provides an overview of the performance qualification (PQ) and performance verification (PV) processes for thermal shipping systems used for local and global transport of temperature-sensitive product shipments. The objective of this technical guidance is to establish an aligned industry best practice for the execution of PQ/PV processes following the completion of the thermal operational qualification (OQ). The content and examples provided in this document are to be used for general industry guidance and awareness to drive a standardized best practice approach for the execution of PQ/PV processes.